TY - JOUR ID - 28055 TI - New Strategy for the Synthesis of Morpholine Cores: Synthesis from N-Propargylamines JO - Iranian Journal of Chemistry and Chemical Engineering JA - IJCCE LA - en SN - 1021-9986 AU - Vessally, Esmail AU - Hosseinian, Akram AU - Edjlali, Ladan AU - Babazadeh, Mirzaagha AU - Hosseinzadeh-Khanmiri, Rahim AD - Department of Chemistry, Payame Noor University, Tehran, I.R. IRAN AD - Department of Engineering Science, College of Engineering, University of Tehran, P.O. Box 11365-4563 Tehran, I.R. IRAN AD - Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, I.R. IRAN Y1 - 2017 PY - 2017 VL - 36 IS - 3 SP - 1 EP - 13 KW - N-propargylamines, Morpholines KW - 6-exo-dig cyclization KW - Cyclo-ketalization KW - Bridged systems DO - 10.30492/ijcce.2017.28055 N2 - Functionalized morpholines have attracted much attention due to their potential biological activities. Despite the wide importance of morpholine derivatives in drug design of various pharmacological agents, the development of new approaches to their synthesis remains relatively unexplored. Given the low cost and easy availability of N-propargylamines, the synthesis of functionalized morpholines from these versatile building blocks have undergone an explosive growth in recent years. This review provides a concise overview of the synthesis of morpholine cores from N-propargyalamines in recent years.  UR - https://ijcce.ac.ir/article_28055.html L1 - https://ijcce.ac.ir/article_28055_dfad0320730bfa99dadeb59d82959f46.pdf ER -