TY - JOUR ID - 23554 TI - One-pot Synthesis and Characterization of Highly Functionalized Thiazoles JO - Iranian Journal of Chemistry and Chemical Engineering JA - IJCCE LA - en SN - 1021-9986 AU - Beyzaei, Hamid AU - Beygi, Adel AU - Aryan, Reza AD - University of Zabol, Zabol, Iran AD - Department of Chemistry, Faculty of Science, University of Zabol, Zabol, I.R. IRAN Y1 - 2016 PY - 2016 VL - 35 IS - 4 SP - 31 EP - 37 KW - One-pot synthesis KW - Thiazole KW - Cyclocondensation KW - Hydrazine KW - Hydrazide DO - 10.30492/ijcce.2016.23554 N2 - A facile and efficient one-pot three-step process for the synthesis of 5-acetyl-2-imino-4-methylthiazoles via the cyclocondensation of 3-thiocyanatoacetylacetone with various hydrazine or hydrazide derivatives in EtOH has been developed. 3-Thiocyanatoacetylacetone itself has been synthesized as the intermediate from substitution reaction of thiocyanate with 3-chloroacetylacetone. Better results were obtained by three-step procedures vs one-step reaction. The proposed method does not require techniques such as extraction and chromatography. Surprisingly, 3,5-dimethyl-4-thiocyanato-1H-pyrazoles were not produced in this reaction, it was proved based on the existence of the acetyl group in the products. The molecular structures of newly synthesized compounds were elucidated on the basis of elemental analysis and spectral data.  UR - https://ijcce.ac.ir/article_23554.html L1 - https://ijcce.ac.ir/article_23554_efe2f2723e2de8a9d2237b5a1181ea3f.pdf ER -