TY - JOUR ID - 12255 TI - The synthesis of Beta-Carbonhomologous Intermediate of Norcardicin A. A General Method for Selective Preparation of The Beta-Lactam Ring in the Presence of Free Phenolic Hydroxyl Groups JO - Iranian Journal of Chemistry and Chemical Engineering JA - IJCCE LA - en SN - 1021-9986 AU - Hakimelahi, Gholam H. AU - Zarrinehzad, Morteza AD - Chemistry Department, Shiraz University, Shiraz, I.R. IRAN Y1 - 1990 PY - 1990 VL - 9 IS - 1 SP - 25 EP - 34 KW - Synthesis of Beta-Carbonhomologous KW - Synthesis of Cis-N-[Beta-carbobenzyloxy-Beta-(p-hydroxyphenyl)ethyl]-3-phathalimido-4-styryl-2-azetidinone KW - mechanisms of cis and trans-Beta-lactam ring formation DO - 10.30492/ijcce.1990.12255 N2 - The synthesis of cis-N-[a-carbobenzyloxy-b-(p-hydroxyphenyl)ethyl]-3-phthalimido-4-styryl-2-azetidinone is described. We have found that the electron-rich Schiff bases can afford the cis-b-lactam ring even in the presence of the free hydroxyl functions. The mechanisms of cis and trans-b-lactam ring formation are discussed. The discussions are consistent with the recent publications. UR - https://ijcce.ac.ir/article_12255.html L1 - https://ijcce.ac.ir/article_12255_edcfd7861d93ee7dc51fc2988c12b33b.pdf ER -