%0 Journal Article %T Optimization of Atropine Extraction Process from Atropa Belladonna by Modified Bubble Column Extractor with Ultrasonic Bath %J Iranian Journal of Chemistry and Chemical Engineering %I Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR %Z 1021-9986 %A Abbaspour, Akbar %A Khadiv Parsi, Parissa %A Khalighi-Sigaroodi, Farahnaz %A Ghaffarzadegan, Reza %D 2016 %\ 12/01/2016 %V 35 %N 4 %P 49-60 %! Optimization of Atropine Extraction Process from Atropa Belladonna by Modified Bubble Column Extractor with Ultrasonic Bath %K Atropine %K Bubble column extraction %K Uniform design %K UV-Visible spectroscopy %K Atropa belladonna %R 10.30492/ijcce.2016.23556 %X Modified Bubble Column Extraction with Ultrasonic Bath (BCE-UB) method was used to extract atropine from the stem and leaves of Atropa belladonna. Optimum condition were obtained with Kamada solvent which was chloroform-methanol-ammonia 15:15:1(v/v/v) as extraction solvent, the particle size of  less than  350 µm, an extraction time of 23.95 min, a liquor to material ratio of 15.08 mL/g and  an  air  flow of  6.31 mL/min.g. In this state, percent of extracted atropine was calculated which was equal to 6.81%. Percent of extracted atropine was 6.31% that showed a little difference compared to the predicted value. In order to study the effect of bubbles on the extraction rate, the same extraction with the previous method was performed in a stirred tank. Percent of atropine was 5.59%. %U https://ijcce.ac.ir/article_23556_c8658b3ac0ad7008631b8e029ae03d22.pdf