@article { author = {Aliabadi, Ali Reza and Harasami Neek, Hojat and Bahmani, Yazdan}, title = {4-Halo-N-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)benzamide and Benzothioamide Derivatives: Synthesis and in vitro Anticancer Assessment}, journal = {Iranian Journal of Chemistry and Chemical Engineering}, volume = {39}, number = {5}, pages = {35-44}, year = {2020}, publisher = {Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR}, issn = {1021-9986}, eissn = {}, doi = {10.30492/ijcce.2020.38207}, abstract = {Cancer is a lethal disorder that has caused a serious threat to human health and nowadays there is a crucial need for the development of novel anticancer agents. A new series of 1,3,4-thiadiazole-based compounds were synthesized and evaluated for anti-cancer properties in vitro. The synthesis of 5-(Trifluoromethyl)-1,3,4-thiadiazol-2-amine (3) was carried out via solvent-free conditions and consequently, benzamide (4a-4f) and benzothioamide (5a-5f) derivatives bearing halogen moieties  (Cl, F) were synthesized. MTT assay was applied for in vitro cytotoxicity assessment against three cancerous cell lines consist of PC3 (Prostate cancer), HT-29 (Colon cancer), and SKNMC (Neuroblastoma). All tested derivatives exhibited equal or more (IC50 = 3-7 µM) cytotoxic activity than doxorubicin (IC50 = 7 µM) as a reference drug against PC3 cell line. Chlorine containing benzamideas well as benzothioamide derivatives (IC50 = 14-36 µM) were also exerted a higher cytotoxic activity against SKNMC cell line compared to doxorubicin (IC50 = 40 µM).}, keywords = {Synthesis,1,3,4-Thiadiazole,Anticancer,MTT assay}, url = {https://ijcce.ac.ir/article_38207.html}, eprint = {https://ijcce.ac.ir/article_38207_873d818b51362e39b3706361c4bdac6e.pdf} }