@article { author = {Shaabani, Ahmad and Mofakham, Hamid and Hajishaabanha, Fatemeh and Mousavi Faraz, Sajjad and Pedarpour Vajargahy, Milad}, title = {A Novel Strategy of Ugi-4CR/Huisgen 1,3-Dipolar Synthesis of 1H-1,2,3-Triazole-Modified Peptidoimetics}, journal = {Iranian Journal of Chemistry and Chemical Engineering}, volume = {37}, number = {2}, pages = {73-84}, year = {2018}, publisher = {Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR}, issn = {1021-9986}, eissn = {}, doi = {10.30492/ijcce.2018.29053}, abstract = {In this protocol, we report a novel approach for the synthesis of a new class of heterocyclic 1H-1,2,3-triazole-modified peptidomimetic compounds. The process consists of an Ugi four-component condensation reaction of amines, an isocyanide, an aldehyde and acids followed by a Huisgen 1,3-dipolar cycloaddition reaction with an azide group in the presence of a catalytic amount of CuSO4.5H2O/sodium ascorbate. The copper-catalyzed Huisgen cycloaddition reactions provide such a general synthetic method, with the resulting 1,2,3-triazoles being good peptide bond mimics. This protocol was highly efficient for structurally diverse heterocyclic molecules containing an active aldehyde group and will find applications in combinatorial chemistry, diversity-oriented synthesis, and drug discovery.}, keywords = {1H-1,2,3-Triazole,1,3-Dipolar cycloaddition,Ugi four-component,Isocyanide}, url = {https://ijcce.ac.ir/article_29053.html}, eprint = {https://ijcce.ac.ir/article_29053_d1e70977e5a90de53c01af2a01d834f7.pdf} }