@article { author = {Shiri, Morteza and Mohamed Heravi, Majid and Zadsirjan, Vahideh and Nejatinezhad-Arani, Atefeh and Shintre, Suhas Ashok and Koorbanally, Neil Anthony}, title = {Pseudo-Five-Component Condensation for the Diversity-Oriented Synthesis of Novel Indoles and Quinolines Containing Pseudo-Peptides (Tricarboxamides)}, journal = {Iranian Journal of Chemistry and Chemical Engineering}, volume = {37}, number = {4}, pages = {101-115}, year = {2018}, publisher = {Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR}, issn = {1021-9986}, eissn = {}, doi = {10.30492/ijcce.2018.28213}, abstract = {A novel series of indole and quinoline tricarboxamides were synthesized using simple and efficient one-pot pseudo-five-component reactions of 2-formylindole or 2-chloro-3-formyl quinolines, isocyanides, amines, and Meldrum’s acid as a CH-acid in CH2Cl2 at room temperature. This conversion has been achieved via the construction of new bonds including two C-C bonds, two C-N bonds, and one C=O bond. Remarkably, three peptide bonds were formed through a domino sequence including Knoevenagel reaction, [1+4] cycloaddition, deacetonation and also, aminolysis reaction. Particularly, a number of structurally remarkable and pharmacologically significant products were provided in excellent yields.}, keywords = {2-formylindole,2-chloro-3-formyl quinolone,isocyanides,Meldrum’s acid,multicomponent reaction,tricarboxamide}, url = {https://ijcce.ac.ir/article_28213.html}, eprint = {https://ijcce.ac.ir/article_28213_fe78afbfbacb0eb77ccffc182226c60b.pdf} }