@article { author = {Vessally, Esmail and Hosseinian, Akram and Edjlali, Ladan and Babazadeh, Mirzaagha and Hosseinzadeh-Khanmiri, Rahim}, title = {New Strategy for the Synthesis of Morpholine Cores: Synthesis from N-Propargylamines}, journal = {Iranian Journal of Chemistry and Chemical Engineering}, volume = {36}, number = {3}, pages = {1-13}, year = {2017}, publisher = {Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR}, issn = {1021-9986}, eissn = {}, doi = {10.30492/ijcce.2017.28055}, abstract = {Functionalized morpholines have attracted much attention due to their potential biological activities. Despite the wide importance of morpholine derivatives in drug design of various pharmacological agents, the development of new approaches to their synthesis remains relatively unexplored. Given the low cost and easy availability of N-propargylamines, the synthesis of functionalized morpholines from these versatile building blocks have undergone an explosive growth in recent years. This review provides a concise overview of the synthesis of morpholine cores from N-propargyalamines in recent years. }, keywords = {N-propargylamines, Morpholines,6-exo-dig cyclization,Cyclo-ketalization,Bridged systems}, url = {https://ijcce.ac.ir/article_28055.html}, eprint = {https://ijcce.ac.ir/article_28055_dfad0320730bfa99dadeb59d82959f46.pdf} }