@article { author = {Abbaspour, Akbar and Khadiv Parsi, Parissa and Khalighi-Sigaroodi, Farahnaz and Ghaffarzadegan, Reza}, title = {Optimization of Atropine Extraction Process from Atropa Belladonna by Modified Bubble Column Extractor with Ultrasonic Bath}, journal = {Iranian Journal of Chemistry and Chemical Engineering}, volume = {35}, number = {4}, pages = {49-60}, year = {2016}, publisher = {Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR}, issn = {1021-9986}, eissn = {}, doi = {10.30492/ijcce.2016.23556}, abstract = {Modified Bubble Column Extraction with Ultrasonic Bath (BCE-UB) method was used to extract atropine from the stem and leaves of Atropa belladonna. Optimum condition were obtained with Kamada solvent which was chloroform-methanol-ammonia 15:15:1(v/v/v) as extraction solvent, the particle size of  less than  350 µm, an extraction time of 23.95 min, a liquor to material ratio of 15.08 mL/g and  an  air  flow of  6.31 mL/min.g. In this state, percent of extracted atropine was calculated which was equal to 6.81%. Percent of extracted atropine was 6.31% that showed a little difference compared to the predicted value. In order to study the effect of bubbles on the extraction rate, the same extraction with the previous method was performed in a stirred tank. Percent of atropine was 5.59%.}, keywords = {Atropine,Bubble column extraction,Uniform design,UV-Visible spectroscopy,Atropa belladonna}, url = {https://ijcce.ac.ir/article_23556.html}, eprint = {https://ijcce.ac.ir/article_23556_c8658b3ac0ad7008631b8e029ae03d22.pdf} }