@article { author = {Golabi, S. Mehdi and Fazli, Massoud and Rastegar Mirzaei, Yousef}, title = {Electrochemical Behaviour of Nifedipine and Nitrendipine in Chloroform and Chloroform-Isopropanol Mixture}, journal = {Iranian Journal of Chemistry and Chemical Engineering}, volume = {17}, number = {1}, pages = {21-28}, year = {1998}, publisher = {Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR}, issn = {1021-9986}, eissn = {}, doi = {10.30492/ijcce.1998.10309}, abstract = {The electrochemical behavior of nifedipine (I), nitrendipine(II) and their photodegradation products has been studied by employing electrochemical techniques in chloroform and in 1:4 mixture of chloroform-isopropanol using piperidinium perchlorate (PPC) as supporting electrolyte. It has been shown that I and II undergo in a 4e, 4H+ irreversible reduction reaction, while the reduction product, phenylhydroxylamine, is oxidized in a 2e, 2H+ reversible process to an unstable nitrosophenyl compound. Photodegradation of I and II by sunlight produces a nitrosophenyl derivative which is reversibly reduced to the corresponding unstable phenylhydroxylamine. No significant change is observed in electrochemical properties of drugs by passing from chloroform to chloroform-isopropanol mixture. The possibility of analysis of I and II by dp polarography is also verified.}, keywords = {Nifedipine,Nitrendipine,Chloroform,Polarography,Cyclic voltammetry}, url = {https://ijcce.ac.ir/article_10309.html}, eprint = {https://ijcce.ac.ir/article_10309_8e7068cd1c02d065f719cead82a1d878.pdf} }