Mining Biological Repetitive Sequences Using Support Vector Machines and Fuzzy SVM
Hesam
Torabi Dashti
Laboratory of Systems Biology and Bioinformatics (LBB), Institute of Biochemistry & Biophysics (IBB), University of Tehran, Tehran, I.R. IRAN
author
Ali
Masoudi-Nejad
Laboratory of Systems Biology and Bioinformatics (LBB), Institute of Biochemistry & Biophysics (IBB), University of Tehran, Tehran, I.R. IRAN
author
text
article
2010
eng
Structural repetitive subsequences are most important portion of biological sequences, which play crucial roles on corresponding sequence’s fold and functionality. Biggest class of the repetitive subsequences is “Transposable Elements” which has its own sub-classes upon contexts’ structures. Many researches have been performed to criticality determine the structure and function of repetitive subsequences. The sequencing noises and the sequences’ substitutions probability are obstacles of these researches. Some statistical and approximation algorithms have introduced to tackle these obstacles. By introducing conspicuous statistical machine learning methods upon Support Vector Machines, machine learning approaches act as potent methods to solve the pattern-finding problem. Support vector machines methods are time efficient approaches, which based on their parameters can be precise and accurate. In this Review, mathematical definition of structural repetitive subsequences are introduced, thereafter proposed algorithm to tackle simple pattern finding problem, which can be applicable on structural patterns are reviewed. Theoretical aspects of Support Vector Machines on computational biology platform are considered. Finally, novel evolutionary Fuzzy SVM will be introduced, which is applicable on wide range of bioinformatics problems especially the problem of structural repetitive subsequences.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
1
17
https://ijcce.ac.ir/article_6367_d4960b6e417e5fb91f9d904507350638.pdf
dx.doi.org/10.30492/ijcce.2010.6367
Integration and Reduction of Microarray Gene Expressions Using an Information Theory Approach
Reza
Shamsaee
Faculty of Computer Engineering, Iran University of Science and Technology (IUST), Tehran, I.R. IRAN
author
Mahmood
Fathy
Faculty of Computer Engineering, Iran University of Science and Technology (IUST), Tehran, I.R. IRAN
author
Ali
Masoudi-Nejad
Laboratory of Systems Biology and Bioinformatics (LBB), Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, I.R. IRAN
author
text
article
2010
eng
The DNA microarray is an important technique that allows researchers to analyze many gene expression data in parallel. Although the data can be more significant if they come out of separate experiments, one of the most challenging phases in the microarray context is the integration of separate expression level datasets that have gathered through different techniques. In this paper, we present a general novel method for the integration of any collected data whose distributions have been linearly transformed. The new method is based on the information theory concepts. More than that, this article presents a new approach for checking of the linearity between two distributions as a validation technique. The validation technique assists in taking the feature reduction process in effect prior to the integration phase. The time complexity of the proposed algorithm is low and the new presented methods show good functionality. The experimental results are presented at the end of the paper.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
19
29
https://ijcce.ac.ir/article_6396_753f8cde34c14642611c0516b9abb3bc.pdf
dx.doi.org/10.30492/ijcce.2010.6396
A Microcalorimetry Study of the Binding of Nickel Ion by Human Growth Hormone
Ali Akbar
Saboury
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, I.R. IRAN
author
Safoura
Amiri
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, I.R. IRAN
author
text
article
2010
eng
A binding study of nickel ions by a new recombinant human Growth Hormone (hGH), produced as an injected drug, has been done at 27˚C in NaCl solution (50 mM) using an isothermal titration calorimetry. There is a set of three identical and non-interacting binding sites for nickel ions. The intrinsic dissociation equilibrium constant and the molar enthalpy of binding are 40 μM and -16.5 kJ/mol, respectively. Thermodynamic parameters of nickel ion binding are compared to the other metal ions. The molar entropy of binding is 29.3 J K-1 mol-1 for Ni2+, less than Cu2+ and more than other metal ions, means that the disorder of the protein structure due to the binding of nickel ions is more than to the other ion metals, except Cu2+. It is expected that nickel ions can prevent from the aggregation of the protein.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
31
36
https://ijcce.ac.ir/article_6397_916950c3c45b35ab9e7739e6a7bb308b.pdf
dx.doi.org/10.30492/ijcce.2010.6397
Comparison of Different Loop Bioreactors Based on Hydrodynamic Characteristics, Mass Transfer, Energy Consumption and Biomass Production from Natural Gas
Fatemeh
Yazdian
Department of Biotechnology, Faculty of Chemical Engineering, Tarbiat Modares University
P.O. Box 14115-143 Tehran, I.R. IRAN
author
Seyed Abbas
Shojaosadati
Department of Biotechnology, Faculty of Chemical Engineering, Tarbiat Modares University
P.O. Box 14115-143 Tehran, I.R. IRAN
author
Mohsen
Nosrati
Department of Biotechnology, Faculty of Chemical Engineering, Tarbiat Modares University
P.O. Box 14115-143 Tehran, I.R. IRAN
author
Ebrahim
Vasheghani-Farahani
Department of Biotechnology, Faculty of Chemical Engineering, Tarbiat Modares University
P.O. Box 14115-143 Tehran, I.R. IRAN
author
Mohammad Reza
Mehrnia
School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, I.R. IRAN
author
text
article
2010
eng
The performance of a forced-liquid Vertical Tubular Loop Bioreactor (VTLB), a forced-liquid Horizontal Tubular Loop Bioreactor (HTLB) and a gas-induced External Airlift Loop Bioreactor (EALB) were compared for production of biomass from natural gas. Hydrodynamic characteristics and mass transfer coefficients were determined as functions of design parameters, physical properties of gases as well as operational parameters. Moreover, energy consumption for different gas and liquid flow rates was studied. In the EALB, kinematic viscosity (υg) showed its significant role on mixing time, gas hold-up and kLa and the diffusion coefficient of gas in water (Dg) had a remarkable effect on kLa. It was observed from experimental results that the performance of the VTLB was the best for biomass production. Furthermore, the volumetric mass transfer coefficients for air and methane were determined at different geometrical and operational factors. New correlations for mixing time, gas hold-up and kLa were obtained and expressed separately. Also, the different ratios of methane and air were measured and compared for optimum growth in the VTLB, HTLB and EALB.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
37
56
https://ijcce.ac.ir/article_6404_d4a70c452130888810e0e13094538610.pdf
dx.doi.org/10.30492/ijcce.2010.6404
Synthesis and Thermal Properties of Novel Biodegradable ABCBA Pentablock Copolymers from Poly (Ethylene glycol), L-Lactide and p-Dioxanone
Jamshid
Mohammadi-Rovshandeh
Caspian faculty of Engineering, University of Tehran, P.O. Box 43841-119 Rezvanshahr, I.R. IRAN
author
Majid
Abdouss
Department of Chemistry, Amirkabir University of Technology, Tehran, I.R. IRAN
author
Sayed Mehdi
Hoseini
Department of Chemistry, Amirkabir University of Technology, Tehran, I.R. IRAN
author
Mohammad
Imani
Iran Polymer and Petrochemical Institute, Tehran, I.R. IRAN
author
Kamel
Ekhlasi-Kazaj
Department of Chemistry, Faculty of Science, Guilan Universiry, Rasht, I.R. IRAN
author
text
article
2010
eng
In this work, new biodegradable ABCBA type pentablock copolymers with different mole ratio of L-lactide and PPDO-b-PEG-b-PPDO triblock copolymer were synthesized and characterized. In the first step, PPDO-b-PEG-b-PPDO triblock copolymer was synthesized via a ring-opening polymerization of P-DiOxanone (PDO) monomer with Poly (Ethylene Glycol) (PEG) using stannous octoate (Sn(Oct)2) as the catalyst. In the second step, L-lactide monomers (60 or 80 mole ratio) as the end blocks were added to the resulting prepolymer in presence of stannous octoate (Sn(Oct)2) catalyst. In the first step, Poly (Ethylene Glycol) (PEG) and, in the second step, triblock copolymer acts as the macro-initiator. The obtained pentablock copolymers were identified by 1H and 13CNMR spectroscopy. Intrinsic viscosity of the resulting copolymers was measured via dilute solution viscometry in chloroform as the solvent. The thermal properties (such as melting points, melting enthalpy and crystallinity) and thermal degradation behavior were studied by Differential Scanning Calorimetry (DSC) and Thermal Gravimetric Analysis (TGA). From the obtained results, it was seen that the poly (L-lactide) end blocks show similar crystallization behavior like poly (L-lactide) homopolymer and also melting temperature of pentablock copolymers rise with an increase in L-lactide content.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
57
65
https://ijcce.ac.ir/article_6405_0c0964749e0363d7a970ebaf9d9cb6ce.pdf
dx.doi.org/10.30492/ijcce.2010.6405
An Efficient Protocol for the Synthesis of Carboacyclic Nucleosides via Aza-Conjugate Addition Reaction
Mohammad Ali
Zolfigol
Faculty of Chemistry, Bu-Ali Sina University, Hamedan, I.R. IRAN
author
Ardeshir
Khazaei
Faculty of Chemistry, Bu-Ali Sina University, Hamedan, I.R. IRAN
author
Ahmad Reza
Moosavi-Zare
Faculty of Chemistry, Bu-Ali Sina University, Hamedan, I.R. IRAN
author
Abdolkarim
Zare
Department of Chemistry, Payame Noor University (PNU),
Tehran, I.R. IRAN
author
Ali Reza
Hasanijejad
Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr, I.R. IRAN
author
text
article
2010
eng
A new efficient method for the synthesis of carboacyclic nucleosides as biologically interesting compounds via aza-conjugate addition of pyrimidine nucleobases to a,β-unsaturated esters in the presence of catalytic amount of LiOH.H2O (1.2-4.8 mol%) under microwave irradiation is described. This method affords the title compounds in good to excellent yields and in short reaction times.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
67
73
https://ijcce.ac.ir/article_6406_af1dd59e7f68c78ceed0b21ff2e77e8b.pdf
dx.doi.org/10.30492/ijcce.2010.6406
Biodesulfurization of Tabas Coal in Pilot Plant Scale
Farahnaz
Eghbali
Faculty of Chemical Engineering, Isfahan University of Technology,
P.O. Box 84156-83111 Isfahan, I.R. IRAN
author
Mohammad Reza
Ehsani
Faculty of Chemical Engineering, Isfahan University of Technology,
P.O. Box 84156-83111 Isfahan, I.R. IRAN
author
text
article
2010
eng
Sulfur emission from coal combustion presents many environmental problems. The techniques used to reduce the amount of sulfur in coal before combustion, include physical, chemical and biological processes.Biological processes based on degradation of sulfur compounds by microorganisms offer many advantages over the conventional physical and chemical processes. The processes are performed under mild conditions with no harmful reaction products and the value of coal is not affected. In this article the progress achieved to date in biodesulfurization of Tabas coal in pilot plant is reviewed. Effect of particle size and pulp density at constant temperature on coal biodesulfurization investigated in this research. The best results obtained was 45% of pyritic sulfur and 20% of total sulfur in reduction at pulp density of 10% and 0-0.5 mm particle size within 14 days.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
75
78
https://ijcce.ac.ir/article_6407_69b54a1d1b619a9be90f945844f38099.pdf
dx.doi.org/10.30492/ijcce.2010.6407
Sorption Performance of Live and Heat-Inactivated Loofa-Immobilized Phanerochaete chrysosporium in Mercury Removal from Aqueous Solution
Rosa
Bashardoost
Food Engineering and Biotechnology Group, Faculty of Chemical Engineering,
Amirkabir University of Technology, Tehran, I.R. IRAN
author
Farzaneh
Vahabzadeh
Food Engineering and Biotechnology Group, Faculty of Chemical Engineering,
Amirkabir University of Technology, Tehran, I.R. IRAN
author
Soheila
Shokrollahzadeh
Institute of Chemical Technologies, Iranian Research Organization for Science and Technology,
P.O. Box 15815-3538 Tehran, I.R. IRAN
author
Ali Reza
Monazzami
Food Engineering and Biotechnology Group, Faculty of Chemical Engineering,
Amirkabir University of Technology, Tehran, I.R. IRAN
author
text
article
2010
eng
The sorption behavior of loofa-immobilized Phanerochaete chrysosporium mycelia in two forms, Live (L) and Heat-Inactivated (HIA), was studied for the removal of Hg2+ ions from aqueous solution. Using the Langmuir isotherm, the two key parameters for the sorption performance, qm and the coefficient b, were obtained; the qm values for Hg2+ ions were 72.46 mg/g and 92.59 mg/g and the b coefficients were 0.073 L/mg and 0.114 L/mg for the L and HIA biosorbents, respectively. Using the Freundlich isotherm, the values of kF were determined as 13.28 and 21.30, and the values of the coefficient n were 3.22 and 3.51 for the L and HIA biosorbents, respectively. Although the biosorption data were well fitted by both the Langmuir and Freundlich models, the Langmuir isotherm gave a better fit, with a higher correlation coefficient than the Freundlich model. Moreover, the essential characteristic of the Langmuir isotherm model, described as the separation factor, was indicative of the favorable adsorption of Hg2+ onto both of the test biosorbents (02ads were 1.16×10-3 g/mg·min and 1.08×10-3 g/mg·min for the L and HIA biosorbents, respectively. Regenerating the biosorbents was possible using hydrochloric acid to leach the sequestered mercury ions, providing an easy way to reduce the cost of the process. The prevailing criteria in the industrial selection and use of biosorbents were satisfactorily met by this system.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
79
89
https://ijcce.ac.ir/article_6408_261cb887da7c74bbdd9e45b0345588ea.pdf
dx.doi.org/10.30492/ijcce.2010.6408
Removal of BTX Compounds from Wastewaters Using Template Free MFI Zeolitic Membrane
Rezvan
Torkaman
Faculty of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, I.R. IRAN
author
Hossein
Kazemian
Department of Chemical and Biochemical Engineering, Faculty of Engineering,
University of Western Ontario (UWO), London, Ontario, CANADA
author
Mohammad
Soltanieh
Faculty of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, I.R. IRAN
author
text
article
2010
eng
MFI zeolite membranes were prepared on porous α-alumina substrates, using secondary growth of nano-seeded layers. The resulting membranes were characterized by means of Scanning Electron Microscopy (SEM), X-Ray Diffractometry (XRD), and pervaporation performance tests for separation of Benzene, Toluene and Xylene (BTX) mixture from contaminated water. The morphology, thickness, homogeneity, crystal preferential orientation and permeation properties of these membranes have been studied in relation to the seed layers. Successful separation of BTX mixture from water was performed by using the manufactured MFI zeolite membrane. The influence of temperature, feed concentration on the membrane separation efficiency systematically investigated. The total permeation fluxes were found to increase with increase in temperature and feed concentration. The separation factors increased with increasing feed concentration and decreased with increasing in temperature.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
91
98
https://ijcce.ac.ir/article_6409_c7129347fd59f6029285fb7a6db3e369.pdf
dx.doi.org/10.30492/ijcce.2010.6409
Microwave Assisted Synthesis of Nano Zeolite Seed for Synthesis Membrane and Investigation of its Permeation Properties for H2 Separation
Simin
Sistani
Faculty of Chemical Engineering, Isfahan University of Technology,
P.O. Box 84156-83111 Isfahan, I.R. IRAN
author
Mohammad Reza
Ehsani
Faculty of Chemical Engineering, Isfahan University of Technology,
P.O. Box 84156-83111 Isfahan, I.R. IRAN
author
Hossein
Kazemian
Department of Chemical and Biochemical Engineering, Faculty of Engineering,
The University of Western Ontario (UWO), Ontario, CANADA
author
text
article
2010
eng
MFI-type zeolite membranes (ZSM-5) were prepared on α-alumina tubular supports and tested for separation of H2/CO mixtures. The effect of pressure and temperature on H2 and CO flows and selectivity was investigated. The best results in this work were obtained with a ZSM-5 membrane prepared over a porous α-alumina tube seeded with zeolite nanocrystals synthesized with microwave technique. In this case the H2 permeance was obtained 2.8 × 10-6 mol/ (m2.s.Pa) with a H2/CO ideal selectivity of 4.9 at 373 K. The permeation results of four gas (H2, CO, N2, CH4) on the synthesized membrane were also investigated.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
99
104
https://ijcce.ac.ir/article_6411_3ffcb5830a0087accd0d86a2a9238669.pdf
dx.doi.org/10.30492/ijcce.2010.6411
Preparation and Characterization of Microfiltration Membrane Embedded with Silver Nano-Particles
Sayed Siavash
Madaeni
Membrane Research Center, Department of Chemical Engineering, Razi University, Kermanshah, I.R. IRAN
author
Tina
Akbarzadeh Arbatan
Department of Chemistry, Tarbiat Moalem University, Tehran, I.R. IRAN
author
text
article
2010
eng
The microfiltration 0.2 µm Cellulose Acetate (CA) membrane was modified by embedding antibacterial silver nano-particles in the membrane pores. This novel technique was developed to enhance the capability of the microfiltration membrane for removing microorganism including bacteria. The prepared membrane was characterized using Scanning Electron Microscopy (SEM), Energy-Dispersive X-ray Spectroscopy (EDS), water contact angle measurement and Differential Scanning Calorimetry (DSC). Membrane performance was elucidated by flux and rejection measurements using water samples from the pond of a public recreational park in Tehran. For rejection capability of the membrane, the availability of filament and c-shaped species of the phyla Actinobacteria and Spirochetas in the permeate side of the membrane was estimated. Contrary to virgin membrane, the modified membrane was able to remove 100% of Actinobacteria and Spirochetasspecies from the infected water. Moreover, the wettability of the modified membrane was remarkably changed leading to higher water flux. A potential application of the modified Ag-CA membrane is “sterile filtration” of temperature sensitive fluids.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
105
111
https://ijcce.ac.ir/article_6412_06f7ee09ec9a8048799965ff61feff94.pdf
dx.doi.org/10.30492/ijcce.2010.6412
Novel High Capacity Swelling Superabsorbent Composite and Its Potential for Controlled Release of Fertilizers
Ali
Pourjavadi
Polymer Research Laboratory, Faculty of Chemistry, sharif University of Technology,
P.O. Box 11365-9516 Tehran, I.R. IRAN
author
Rouhollah
Soleyman
Polymer Research Laboratory, Faculty of Chemistry, sharif University of Technology, P.O. Box 11365-9516 Tehran, I.R. IRAN
author
Ghasem
Rezanejad Bardajee
Department of Chemistry, Payame Noor University, Gazvin Branch, P.O. Box 878 Qazvin, I.R. IRAN
author
text
article
2010
eng
A hydrophilic macromolecular network is prepared by performing graft copolymerization of poly (sodium acrylate) chains onto salep and silica gel. The reaction parameters affecting the water absorbency of the superabsorbent composite were optimized using Taguchi method. FT-IR spectroscopy and Thermo Gravimetric Analysis (TGA) were used for confirming the structure of the final product and morphology of the synthesized superabsorbent composite was examined by SEM. The swelling behavior of optimum superabsorbent composite was measured in various swelling media. In addition, swelling kinetics and on-off switching behavior were investigated. In order to evaluate the controlled release potential of the matrix, it was loaded with KNO3 and NH4NO3 as a model agrochemical and the release kinetics was studied.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
113
123
https://ijcce.ac.ir/article_6413_6e49dcfe17008e9ab2bae0066b5335dc.pdf
dx.doi.org/10.30492/ijcce.2010.6413
Adsorption of Bovine Serum Albumin onto Hydroxylapatite: Theoretical Modeling and Measurements
Hamid
Modarress
Faculty of Chemical Engineering, Amirkabir University of Technology, Tehran, I.R. IRAN
author
Leila
Allafkari
Faculty of Chemical Engineering, Amirkabir University of Technology, Tehran, I.R. IRAN
author
text
article
2010
eng
Adsorption of Bovine Serum Albumin (BSA) onto calcium Hydroxyl Apatite (HA), Ca10PO4(OH)2, has been studied by Ultra Violet (UV) spectroscopy. The adsorption isotherms of BSA onto the HA surface at 291.7 K and 303.2 K were satisfactorily presented by Langmuir equation and the evaluated parameters are reported. The specific surface area of HA has been measured by the BET method. The obtained value for the used HA sample was 63 m2/g. The effect of pH on BSA adsorption onto the HA in presence of salts KCl and NaF and phosphate ion has been investigated. In the fixed concentration of BSA (1 mg/mL) it is shown that the pH decreasing causes to increase of the adsorption of BSA onto HA. Considering the role of effective factors in BSA adsorption onto HA such as the size and charge of the BSA and the surface energy of HA showed that the electrostatic repulsion forces between HA and BSA cause a decrease in BSA adsorption onto HA. Also the obtained results indicated that the surface energy of HA predominates the effect of size and charge of BSA.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
125
133
https://ijcce.ac.ir/article_6415_90f41838233e2b2564e9f4f47bc1536c.pdf
dx.doi.org/10.30492/ijcce.2010.6415
Olefin Production from Heavy Liquid Hydrocarbon Thermal Cracking: Kinetics and Product Distribution
Mehdi
Sedighi
Faculty of Chemical Engineering, Tarbiat Modares University,
P.O. Box14115-143 Tehran, I.R. IRAN
author
Kamyar
Keyvanloo
Faculty of Chemical Engineering, Tarbiat Modares University,
P.O. Box14115-143 Tehran, I.R. IRAN
author
Jafar
Towfighi Darian
Faculty of Chemical Engineering, Tarbiat Modares University,
P.O. Box14115-143 Tehran, I.R. IRAN
author
text
article
2010
eng
Thermal cracking of a heavy liquid hydrocarbon was performed in a laboratory scale tubular reactor. Central Composite Design (CCD), was used as an experimental design method. The design variables were Coil Outlet Temperature (COT), feed flow and rate steam ratio. Maximum yield of ethylene was 30.37 wt% at COT, residence time and steam ratio of 869oC, 0.208 s and 1.22 g/g, respectively. Maximum yield of propylene was 15.37 wt% at COT, residence time and steam ratio of 825oC, 0.147 s and 0.95 g/g, respectively. A mechanistic model based on free radical chain reactions was developed using experimental results. Developed reaction network contains 148 reactions for 43 species. Finally, the experimental data were compared with model results. Scatter diagrams showed good agreement between model and experimental data.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
135
147
https://ijcce.ac.ir/article_6416_f050b9bd127d40b6208325ffc19a2382.pdf
dx.doi.org/10.30492/ijcce.2010.6416
Control of a Chemical Reactor with Chaotic Dynamics
Shabnam
Rasoulian
Faculty of Chemical and Petroleum Engineering, Sharif University of Technology, P.O. Box 11155-9465 Tehran, I.R. IRAN
author
Mohammad
Shahrokhi
Faculty of Chemical and Petroleum Engineering, Sharif University of Technology,P.O. Box 11155-9465 Tehran, I.R. IRAN
author
Hassan
Salarieh
Faculty of Mechanical Engineering, Sharif University of Technology,
P.O. Box 11155-9567 Tehran, I.R. IRAN
author
text
article
2010
eng
In this paper, control of a non-isothermal continuous stirred tank reactor in which two parallel autocatalytic reactions take place has been addressed. The reactor shows chaotic behavior for a certain set of reactor parameters. In order to control the product concentration, an optimal state feedback controller has been designed. Since concentrations of reactor species are not measured, an observer has been designed for implementation of the proposed control scheme. The local asymptotic stability of the closed-loop system including observer dynamics has been shown via the Lyapunov stability theorem. Effectiveness of the proposed controller in load rejection and set point tracking has been illustrated through simulation.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
149
159
https://ijcce.ac.ir/article_6417_dd49f8bcbe53168d44a714f8b56ef3cd.pdf
dx.doi.org/10.30492/ijcce.2010.6417
CFD Study on Hydrogen-Air Premixed Combustion in a Micro Scale Chamber
Sayed Reza
Shabanian
CFD Research Center, Chemical Engineering Department, Razi University, Kermanshah, I.R. IRAN
author
Masoud
Rahimi
CFD Research Center, Chemical Engineering Department, Razi University, Kermanshah, I.R. IRAN
author
Abbas
Khoshhal
CFD Research Center, Chemical Engineering Department, Razi University, Kermanshah, I.R. IRAN
author
Ammar Abdulaziz
Alsairafi
Faculty of Mechanical Engineering, College of Engineering and Petroleum, Kuwait University, KUWAIT
author
text
article
2010
eng
This paper reports a CFD modeling study to investigate the hydrogen-air mixture combustion in a micro scale chamber. Nine species with nineteen reversible reactions were considered in the premixed combustion model. The effect of operational and geometrical conditions including; combustor size, wall conductivity, reactant flow rates and hydrogen feed splitting on combustion stability and outlet gas temperature were investigated. The results show that the wall thermal conductivity has a significant effect on the combustion especially at smaller chamber size with high ratio of chamber surface area to its volume. In addition, the results reveal that high heat loss from chamber wall, small chamber and high input rate may cause flame quenching. Moreover, the modeling results indicate that a stable combustion in a micro combustor can be achieved at an optimum operational condition.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
161
172
https://ijcce.ac.ir/article_6419_6678a8fdb024762a470936aec79526ab.pdf
dx.doi.org/10.30492/ijcce.2010.6419
Hybrid Nanocomposite Based on CoFe2O4 Magnetic Nanoparticles and Polyaniline
Abdolmajid
Bayandori Moghaddam
Department of Engineering Science, College of Engineering, University of Tehran, P.O. Box 11155-4563 Tehran, I.R. IRAN
author
Samanesadat
Hosseini
Research Institute of Applied Sciences (RIAS)-ACECR, Tehran, I.R. IRAN
author
Jalil
Badraghi
Research Institute of Applied Sciences (RIAS)-ACECR, Tehran, I.R. IRAN
author
Aghdas
Banaei
Research Institute of Applied Sciences (RIAS)-ACECR, Tehran, I.R. IRAN
author
text
article
2010
eng
CoFe2O4 Magnetic Nano Particles (MNPs) were synthesized by an efficient method in aqueous medium with the particle sizes of about 20-50 nm. Then, a hybrid nanocomposite of polyaniline (PANI)-CoFe2O4 MNPs has been electrodeposited directly on a stainless steel wire by the potentiostatic method. Microscopic images of electrodeposited PANI and PANI-CoFe2O4 nanocomposite coatings were obtained by scanning electron microscope. The scanning electron microscopic images of polyaniline and its nanocomposite pointed out the influence of CoFe2O4 nanoparticlesin the electrodeposition of polyaniline. Dispersion of CoFe2O4 nanoparticles in electrolyte solution during the electrodeposition, creates a nanocomposite with a more surface area than pure polyaniline.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
173
179
https://ijcce.ac.ir/article_6484_5064b22ee8c3afe81cd6f3822cded3a7.pdf
dx.doi.org/10.30492/ijcce.2010.6484
The Effect of Process Variables on the Properties of Ketoprofen Loaded Solid Lipid Nanoparticles of Beeswax and Carnauba Wax
Soheila
Kheradmandnia
Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, I.R. IRAN
author
Ebrahim
Vasheghani-Farahani
Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, I.R. IRAN
author
Mohsen
Nosrati
Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, I.R. IRAN
author
Fatemeh
Atyabi
Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences,Tehran, I.R. IRAN
author
text
article
2010
eng
Solid Lipid Nanoparticles (SLNs) have emerged as an alternative colloidal carriers for sustained release of lipophilic drugs with poor absorption and water solubility. This manuscript describes the effect of process variables on the production of Solid Lipid Nanoparticles (SLNs) from beeswax and carnauba wax and ketoprofen release from these carriers. It was found that by increasing drug content from 0.5 to 1.5% w/v the average particle size of SLNs increased from 82 to 116 nm and drug loading increased from 10.7 to 26.6% while entrapment efficiency remained almost constant (≈ 97%). Unexpectedly, the average size of SLNs increased from 82 to 150 nm by increasing homogenization time from 5 to 15 min. Increasing homogenization intensity from 11000 to 24000 rpm resulted in the particle size decrease from 108 to 82 nm. The rate of drug release from nanparticles loaded with 0.5% w/v ketoprofen increased with increasing the ionic concentration of phosphate buffer solution from 0.05 to 0.1 M.
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
181
187
https://ijcce.ac.ir/article_6485_adf948958244241a555baa2b4bf17657.pdf
dx.doi.org/10.30492/ijcce.2010.6485
Synthesis and Cytotoxic Activity of Novel 9-[Hydroxy(Substitutedphenyl) Methyl]-2,2-Dimethyl-2,3,8,9-Tetrahydro-4H,10H-Pyrano [2,3-f ]Chromene-4,10-Diones
Babak
Heidary Alizadeh
Iranian Research Institute of Plant Protection (IRIP), Tehran, I.R. IRAN
author
Mohsen
Vosooghi
Department of Medicinal Chemistry, Faculty of Pharmacy, and Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran, I.R. IRAN
author
Mehdi
Khoobi
Department of Medicinal Chemistry, Faculty of Pharmacy, and Drug Design & Development Research Center, Tehran,
Tehran University of Medical Sciences, I.R. IRAN
author
Azita
Javidnia
Department of Medicinal Chemistry, Faculty of Pharmacy, and Drug Design & Development Research Center, Tehran, Tehran University of Medical Sciences, I.R. IRAN
author
Fatemeh
Panah,
Institute of Biochemistry and Biophysics (IBB), University of Tehran, P.O. Box 13145-1384 Tehran, I.R. IRAN
author
Maliheh
Safavi
Institute of Biochemistry and Biophysics (IBB), University of Tehran, P.O. Box 13145-1384 Tehran, I.R. IRAN
author
Sussan
Ardestani
Institute of Biochemistry and Biophysics (IBB), University of Tehran, P.O. Box 13145-1384 Tehran, I.R. IRAN
author
Abass
Shafiee
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran, Tehran University of Medical Sciences, I.R. IRAN
author
text
article
2010
eng
Chromanone derivatives demonstrate remarkable cytotoxity against a varieties of cancer cell lines. Novel 9-[hydroxy(substitutedphenyl)methyl]-2,2-dimethyl-2,3,8,9- tetrahydro-4H,10H-pyrano[2,3-f]chromene-4,10-diones as Glyasperin analogues were synthesized in four steps from known 4-chromone 1. The key step was the preparation of chromane dione 5a by regioselective intramolecular cyclization reaction in 85% yield. Condensation of 5a with substituted aromatic aldehydes afforded corresponding alpha hydroxybenzyl analogues 6a-6e. The cytotoxic study of the synthesized compounds against breast cancer human cell line (T47D) showed moderate cytotoxic activities (IC50=16-40 μM) compared to the positive control drug vincristin (IC50=2.5 μM).
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
189
196
https://ijcce.ac.ir/article_6486_852e7995780b7fb8bf5c5ad9acab058e.pdf
dx.doi.org/10.30492/ijcce.2010.6486
Theoretical Study of Heteroatom Resonance-Assisted Hydrogen Bond: Effect of Substituent on π-delocalization
Ali Heydar
Pakiari
Chemistry Department, Faculty of Sciences, Shiraz University, Shiraz, I.R. IRAN
author
Maryam
Farrokhnia
Chemistry Department, Faculty of Sciences, Shiraz University, Shiraz, I.R. IRAN
author
text
article
2010
eng
The concept of Resonance Assisted Hydrogen Bond (RAHB), which usually occurs in b diketons, has a remarkable role in chemistry. These molecules, which contain heteroatom particularly O and N, are species with biological interest in protein folding and DNA pairing. Therefore, the amplification of hydrogen bonds strength by substituents may be important in life sciences. In the current research, we have shown that the nature of hydrogen bond in the enol form of heteroatom RAHB systems has partial covalent and electrostatic character. Nonetheless, the strength of hydrogen bonds increases by means of three different groups of substituents, which cannot be attributed to the contributions of resonance structures. Parameters such as bond ellipticity, p delocalization indices and bond equalizations cannot help to prove the effect of conjugation on the strength of hydrogen bond in RAHB systems. It is shown by NBO that the primary and secondary hyperconjugative charge transfer caused by substituents help to amplify this type of hydrogen bond. We showed that the existence of p-conjugation is necessary only for transformation of electron from substituents to the hydrogen bond as an acceptor of electrons.The strength of RAHB has a rather good correlation with the distance between of two non-connected heteroatoms O and N according to reference [62].
Iranian Journal of Chemistry and Chemical Engineering
Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
1021-9986
29
v.
4
no.
2010
197
210
https://ijcce.ac.ir/article_6487_2302cda97a7be1e578598862163f1b1c.pdf
dx.doi.org/10.30492/ijcce.2010.6487